{"id":67,"date":"2021-10-18T19:41:39","date_gmt":"2021-10-18T11:41:39","guid":{"rendered":"https:\/\/linguopeng.top\/?p=67"},"modified":"2024-07-12T23:18:23","modified_gmt":"2024-07-12T15:18:23","slug":"%e7%b3%96%e5%b0%bf%e7%97%85%e9%80%9a%e8%b7%af%e7%ae%80%e4%bb%8b","status":"publish","type":"post","link":"https:\/\/linguopeng.top\/?p=67","title":{"rendered":"\u7cd6\u5c3f\u75c5\u901a\u8def\u79d1\u666e"},"content":{"rendered":"\n<p class=\"has-medium-font-size wp-block-paragraph\">\u8102\u4ee3\u8c22\uff1a<\/p>\n\n\n\n<p class=\"has-normal-font-size wp-block-paragraph\">\u817a\u82f7\u9178\u6d3b\u5316\u86cb\u767d\u6fc0\u9176\uff08AMP activated protein kinase, AMPK\uff09\u662f\u673a\u4f53\u7ef4\u6301\u4f53\u5185\u80fd\u91cf\u5e73\u8861\u4e0e\u7ec6\u80de\u80fd\u91cf\u7a33\u6001\u7684\u5173\u952e\u86cb\u767d\uff0c\u662f\u7814\u7a76\u7cd6\u5c3f\u75c5\u53ca\u5176\u4ed6\u76f8\u5173\u4ee3\u8c22\u75be\u75c5\u7684\u6838\u5fc3[1]\u3002AMPK\u53ef\u8c03\u63a7\u4e0b\u6e38\u5408\u6210\u8102\u80aa\u9178\u76f8\u5173\u7684\u4e59\u9170\u8f85\u9176\uff21\u7fa7\u5316\u91761\uff08Acetyl CoA car boxylase, ACC1\uff09\u548c\u8102\u80aa\u751f\u6210\u8f6c\u5f55\u56e0\u5b50\u56fa\u9187\u8c03\u63a7\u5143\u4ef6\u7ed3\u5408\u86cb\u767d1\uff08Sterol regulatory element binding protein, SREBP1\uff09\u3002AMPK\u53d1\u751f\u78f7\u9178\u5316\u540eAMPK\/SREBP1\u901a\u8def\u88ab\u6fc0\u6d3b\u53ef\u6291\u5236SREBP1\u7684\u6d3b\u6027\uff0c\u589e\u52a0ACC\u78f7\u9178\u5316\u6c34\u5e73\uff0c\u6291\u5236ACC1\u548c\u8102\u80aa\u9178\u5408\u6210\u9176\uff08Fatty acid synthase, FAS\uff09\u7684\u8868\u8fbe\uff0c\u4ece\u800c\u6291\u5236\u8102\u80aa\u5408\u6210[2,3]\u3002\u53ef\u901a\u8fc7\u4ecb\u5bfcAMPK\/SREBP1\u901a\u8def\u51cf\u8f7b\u7cd6\u5c3f\u75c5\u5927\u9f20\u4f53\u5185\u8102\u4ee3\u8c22\u7d0a\u4e71\u3002 <\/p>\n\n\n\n<p class=\"has-medium-font-size wp-block-paragraph\">\u7cd6\u4ee3\u8c22\uff1a<\/p>\n\n\n\n<p class=\"has-normal-font-size wp-block-paragraph\">\u80f0\u5c9b\u7d20\u62b5\u6297\u662fT2DM\u7684\u4e3b\u8981\u5371\u9669\u56e0\u7d20<sup>[4]<\/sup>\u3002PI3K\/AKT\u4fe1\u53f7\u901a\u8def\u5728\u8461\u8404\u7cd6\u7a33\u6001\u3001\u80f0\u5c9b\u7d20\u4fe1\u53f7\u4f20\u5bfc\u8fc7\u7a0b\u4e2d\u8d77\u7740\u6838\u5fc3\u4f5c\u7528\u3002PI3K\u662f\u4e00\u79cd\u78f7\u8102\u9170\u808c\u9187\u6fc0\u9176\uff0c\u7531\u4e00\u4e2a\u50ac\u5316\u4e9a\u57fa\uff08p110\uff09\u548c\u4e00\u4e2a\u8c03\u8282\u4e9a\u57fa\uff08p85\uff09\u7ec4\u6210\uff0c\u53ef\u8c03\u63a7\u4e0b\u6e38\u7cd6\u5f02\u751f\u5173\u952e\u9176\u78f7\u9178\u70ef\u9187\u5f0f\u4e19\u916e\u9178\u7fa7\u6fc0\u91761\uff08phosphoenolpyruvate carboxykinase, PCK1\uff09\u548c\u7cd6\u539f\u5408\u9176\u6fc0\u9176-3\u03b2\uff08glycogen synthase kinase-3\u03b2, GSK-3\u03b2\uff09\u6d3b\u6027\uff0c\u53c2\u4e0e\u8c03\u8282\u8840\u7cd6\u6c34\u5e73\u548c\u5408\u6210\u7cd6\u539f\u8fc7\u7a0b<sup>[5,6]<\/sup>\u3002\u53ef\u6fc0\u6d3bPI3K\/AKT\u4fe1\u53f7\u901a\u8def\u964d\u4f4ePCK1\u548cGSK-3\u03b2\u6d3b\u6027\uff0c\u7cd6\u539f\u5408\u9176\u5408\u6210\u7cd6\u539f\uff0c\u964d\u4f4e\u8840\u7cd6\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><div class='fancybox-wrapper lazyload-container-unload' data-fancybox='post-images' href='https:\/\/linguopeng.top\/wp-content\/uploads\/2024\/05\/-1.png'><img class=\"lazyload lazyload-style-1\" src=\"data:image\/svg+xml;base64,PCEtLUFyZ29uTG9hZGluZy0tPgo8c3ZnIHdpZHRoPSIxIiBoZWlnaHQ9IjEiIHhtbG5zPSJodHRwOi8vd3d3LnczLm9yZy8yMDAwL3N2ZyIgc3Ryb2tlPSIjZmZmZmZmMDAiPjxnPjwvZz4KPC9zdmc+\"  decoding=\"async\" data-original=\"https:\/\/linguopeng.top\/wp-content\/uploads\/2024\/05\/-1.png\" src=\"data:image\/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAYAAAAfFcSJAAAAAXNSR0IArs4c6QAAAARnQU1BAACxjwv8YQUAAAAJcEhZcwAADsQAAA7EAZUrDhsAAAANSURBVBhXYzh8+PB\/AAffA0nNPuCLAAAAAElFTkSuQmCC\" alt=\"\"\/><\/div><\/figure>\n\n\n\n<figure class=\"wp-block-image size-full\"><div class='fancybox-wrapper lazyload-container-unload' data-fancybox='post-images' href='https:\/\/linguopeng.top\/wp-content\/uploads\/2024\/07\/yinduotonglu.png'><img class=\"lazyload lazyload-style-1\" src=\"data:image\/svg+xml;base64,PCEtLUFyZ29uTG9hZGluZy0tPgo8c3ZnIHdpZHRoPSIxIiBoZWlnaHQ9IjEiIHhtbG5zPSJodHRwOi8vd3d3LnczLm9yZy8yMDAwL3N2ZyIgc3Ryb2tlPSIjZmZmZmZmMDAiPjxnPjwvZz4KPC9zdmc+\"  loading=\"lazy\" decoding=\"async\" width=\"1735\" height=\"568\" data-original=\"https:\/\/linguopeng.top\/wp-content\/uploads\/2024\/07\/yinduotonglu.png\" src=\"data:image\/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAYAAAAfFcSJAAAAAXNSR0IArs4c6QAAAARnQU1BAACxjwv8YQUAAAAJcEhZcwAADsQAAA7EAZUrDhsAAAANSURBVBhXYzh8+PB\/AAffA0nNPuCLAAAAAElFTkSuQmCC\" alt=\"\" class=\"wp-image-754\"  sizes=\"auto, (max-width: 1735px) 100vw, 1735px\" \/><\/div><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">[1]\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 \u9648\u91d1\u57ce, \u5f20\u541f. AMPK\u4e0e\u809d\u810f\u7cd6\u5f02\u751f\u7814\u7a76\u8fdb\u5c55[J]. \u4e2d\u56fd\u73b0\u4ee3\u5e94\u7528\u836f\u5b66, 2017, 34(7): 1062\u20131067. DOI:10.13748\/j.cnki.issn1007-7693.2017.07.030<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">[2]&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; ZHAO Z, WANG C, ZHANG L, et al. Lactobacillus plantarum NA136 improves the non-alcoholic fatty liver disease by modulating the AMPK\/Nrf2 pathway[J]. Applied Microbiology and Biotechnology, 2019, 103(14): 5843\u20135850. DOI:10.1007\/s00253-019-09703-4.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">[3]&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; QUAN H Y, KIM D Y, KIM S J, et al. Betulinic acid alleviates non-alcoholic fatty liver by inhibiting SREBP1 activity via the AMPK-mTOR-SREBP signaling pathway[J]. Biochemical Pharmacology, Elsevier Inc., 2013, 85(9): 1330\u20131340. DOI:10.1016\/j.bcp.2013.02.007.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">[4]&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; GAO Z, ZHANG X, ZUBERI A, et al. Inhibition of insulin sensitivity by free fatty acids requires activation of multiple serine kinases in 3T3-L1 adipocytes[J]. Molecular Endocrinology, 2004, 18(8): 2024\u20132034. DOI:10.1210\/me.2003-0383.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">[5]&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; MACAULAY K, WOODGETT J R. Targeting glycogen synthase kinase-3 (GSK-3) in the treatment of Type 2 diabetes[J]. Expert Opinion on Therapeutic Targets, 2008, 12(10): 1265\u20131274. DOI:10.1517\/14728222.12.10.1265.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">[6]&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; LI X, WANG E, YIN B, et al. Effects of lactobacillus casei CCFM419 on insulin resistance and gut microbiota in type 2 diabetic mice[J]. Beneficial Microbes, 2017, 8(3): 421\u2013432. DOI:10.3920\/BM2016.0167.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u8102\u4ee3\u8c22\uff1a \u817a\u82f7\u9178\u6d3b\u5316\u86cb\u767d\u6fc0\u9176\uff08AMP activated protein kinase, AMPK\uff09\u662f\u673a\u4f53\u7ef4\u6301 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[11],"class_list":["post-67","post","type-post","status-publish","format-standard","hentry","category-uncategorized","tag-11"],"_links":{"self":[{"href":"https:\/\/linguopeng.top\/index.php?rest_route=\/wp\/v2\/posts\/67","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/linguopeng.top\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/linguopeng.top\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/linguopeng.top\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/linguopeng.top\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=67"}],"version-history":[{"count":5,"href":"https:\/\/linguopeng.top\/index.php?rest_route=\/wp\/v2\/posts\/67\/revisions"}],"predecessor-version":[{"id":755,"href":"https:\/\/linguopeng.top\/index.php?rest_route=\/wp\/v2\/posts\/67\/revisions\/755"}],"wp:attachment":[{"href":"https:\/\/linguopeng.top\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=67"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/linguopeng.top\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=67"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/linguopeng.top\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=67"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}